• The acute effect of smoking in healthy and asthmatic smokers 

      Papaioannou, A. I.; Koutsokera, A.; Tanou, K.; Kiropoulos, T. S.; Tsilioni, I.; Oikonomidi, S.; Liadaki, K.; Pournaras, S.; Gourgoulianis, K. I.; Kostikas, K. (2010)
      Background Acute exposure to cigarette smoke is related to airway and systemic inflammation and oxidative stress. Little is known about the acute effect of cigarette smoking in smoking asthmatics. The aim of this study was ...
    • Acute phase markers for the differentiation of infectious and malignant pleural effusions 

      Kiropoulos, T. S.; Kostikas, K.; Oikonomidi, S.; Tsilioni, I.; Nikoulis, D.; Germenis, A.; Gourgoulianis, K. I. (2007)
      Acute-phase markers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), have been studied in inflammatory and malignant disorders. We examined the diagnostic value of these ...
    • Adiposity and Low-Grade Systemic Inflammation Modulate Matrix Metalloproteinase-9 Levels in Greek Children With Sleep Apnea 

      Kaditis, A. G.; Alexopoulos, E. I.; Karathanasi, A.; Ntamagka, G.; Oikonomidi, S.; Kiropoulos, T. S.; Zintzaras, E.; Gourgoulianis, K. (2010)
      Background: Matrix metalloproteinase-9 (MMP-9) plasma levels correlate with C-reactive protein (CRP) concentrations and they are both increased in adults with obstructive sleep apnea (OSA). No studies have evaluated MMP-9 ...
    • Diagnostic accuracy of biomarkers of oxidative stress in parapneumonic pleural effusions 

      Tsilioni, I.; Kostikas, K.; Kalomenidis, I.; Oikonomidi, S.; Tsolaki, V.; Minas, M.; Gourgoulianis, K. I.; Kiropoulos, T. S. (2011)
      P>Background The imbalance between oxidants and antioxidants is referred to as oxidative stress and has been associated with various respiratory disorders. The aim of this study was the assessment of 8-isoprostane (8-iso-PGF(2 ...
    • Hyaluronic acid levels are increased in complicated parapneumonic pleural effusions 

      Zaga, T.; Makris, D.; Tsilioni, I.; Kiropoulos, T.; Oikonomidi, S.; Damianos, A.; Gourgoulianis, K. I. (2011)
      Background and Aim. Hyaluronic acid (HA) is a component of extracellular matrix and may play a role in the pleural inflammation which is implicated in parapneumonic effusions.The aim of the current study was to investigate ...
    • Matrix Metalloproteinase Levels in the Differentiation of Parapneumonic Pleural Effusions 

      Oikonomidi, S.; Kostikas, K.; Kalomenidis, I.; Tsilioni, I.; Daenas, C.; Gourgoulianis, K. I.; Kiropoulos, T. S. (2010)
      Background: Matrix metalloproteinases (MMPs) have been implicated in the escalation of fibrosis and remodeling which are central to the subsequent progression of a parapneumonic pleural effusion to empyema. Objectives: The ...
    • Matrix Metalloproteinases in Respiratory Diseases: From Pathogenesis to Potential Clinical Implications 

      Oikonomidi, S.; Kostikas, K.; Tsilioni, I.; Tanou, K.; Gourgoulianis, K. I.; Kiropoulos, T. S. (2009)
      Matrix metalloproteinases (MMPs) are zinc-endopeptidases responsible for degradation of the extracellular matrix (ECM) components including basement membrane collagen, interstitial collagen, fibronectin, and various ...
    • Residual Pleural Thickening Is Related to Vascular Endothelial Growth Factor Levels in Parapneumonic Pleural Effusions 

      Papaioannou, A. I.; Kostikas, K.; Tsopa, P.; Kiropoulos, T.; Tsilioni, I.; Oikonomidi, S.; Gerogianni, I.; Gourgoulianis, K. I. (2010)
      Background: Many patients with pneumonia develop pleural effusions. Pleural fluid vascular endothelial growth factor (VEGF) levels are known to be elevated in complicated parapneumonic effusion and seem to play a major ...
    • Serum Amyloid Alpha in Parapneumonic Effusions 

      Boultadakis, V.; Skouras, V.; Makris, D.; Damianaki, A.; Nikoulis, D. J.; Kiropoulos, T.; Oikonomidi, S.; Tsilioni, I.; Gourgoulianis, K. (2011)
      Study objectives. To assess serum amyloid alpha (SAA) pleural fluid levels in parapneumonic effusion (PPE) and to investigate SAA diagnostic performance in PPE diagnosis and outcome. Methods. We studied prospectively 57 ...